Details

Zic family


Zic family

Evolution, Development and Disease
Advances in Experimental Medicine and Biology, Band 1046

von: Jun Aruga

178,49 €

Verlag: Springer
Format: PDF
Veröffentl.: 13.02.2018
ISBN/EAN: 9789811073113
Sprache: englisch

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Beschreibungen

This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine.   
Part1: Zic family in animal evolution and development. Comparative genome analysis of Zic genes.- Drosophila Zic genes.- Nematode Zic genes.- Planarian Zic genes.- Ascidian  (Halocynthia) Zic genes.- Ascidian  (Ciona) Zic genes.- Amphibian Zic genes.- Teleost fish  (Oryzias) Zic genes.- Teleost fish (Danio) Zic genes.- Overview of rodent Zic genes.- Rodent Zic genes in neural network wiring.- Rodent Zic genes in meninx and vasculature development.- Part2?ZIC family in Medicine: ZIC family as the causative genes for developmental disorders. ZIC1 in Dandy-Walker malformation.- ZIC2 in holoprosencephaly  Maximilian.- Ch.16 ZIC3 in heterotaxy.- Part3?ZIC family in Medicine: ZIC family in stem cell biology. Role of Zic family in transcriptional regulation and chromatin remodeling.- Deregulation of ZIC family in oncogenesis.- ZIC family and stemness.-  ZIC2 in cancer stem cell.
Jun Aruga is a professor of pharmacology at Nagasaki University Institute of Biomedical Sciences, and a former head of the Laboratory for Behavioral and Developmental Disorder at RIKEN Brain Science Institute. He has been researching the biological significance of ZIC family genes since their discovery in 1991.
This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine.   
Is the first comprehensive review of the Zic family-related studies in biology and medicinePresents the Zic genes for the nervous system appearance is utilized in the animal evolutionProvides the cutting edge information for common genetic disorders, stem cell and cancer cell biology 
Is the first comprehensive review of the Zic family-related studies in biology and medicinePresents the Zic genes for the nervous system appearance is utilized in the animal evolutionProvides the cutting edge information for common genetic disorders, stem cell and cancer cell biology 

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